In addition to the intestine, the FXR agonist also activates FXR receptors in the liver which can provide additional regulation of bile acid synthesis and maintenance of the bile acid pool.
Step 3 of 4
Once in the liver FGF19, binds to its receptor and causes a decrease in the synthesis of bile acids.
Step 2 of 4
FXR receptor activation causes cells in the intestine to release a protein called FGF19 which travels to the liver
Step 1 of 4
The FXR drug (agonist) is taken orally and travels through the stomach to the intestine. In the intestine the FXR agonist binds to and activates the FXR receptor.